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This may be explained by the fact that testosterone levels are far higher in the testes than in the rest of the body (concentrations in the (which make up approximately 80% of the bulk of the testes) are 20- to 100-fold greater than circulating levels), and on account of the extremely high levels of androgens that are present, it is likely that systemic bicalutamide therapy is unable to produce intratesticular concentrations of the drug that are able to significantly block androgen action in this part of the body.
Bicalutamide is used to treat prostate cancer that has spread to other areas of the body.
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Other adverse experiences (greater than or equal to 2%, but less than 5%) reported in the CASODEX-LHRH analogue treatment group are uled below by body system and are in order of decreasing frequency within each body system regardless of causality.
In addition, when a base such as triethylamine and the like is used, the above-mentioned reaction solvent such as toluene and the like may or may not be used as a solvent.
Women Bicalutamide has no indication for women, and should not be used in this population.
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This mutation has been shown to cause a significant increase in the affinity of the AR for binding to estrogens and progesterone.
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Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.
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We undertook a meta-analysis to assess the efficacy of various treatment options for bicalutamide-induced gynecomastia.
Cancer of the prostate depends on the male hormone testosterone for its growth.
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Dynamic changes of alkaline phosphatase are strongly associated with PSA-decline and predict best clinical benefit earlier than PSA-changes under therapy with abiraterone acetate in bone metastatic castration resistant prostate cancer.
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The use of PSA recurrence as a measure of long-term disease control.
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Prior treatment with certain types of chemotherapy and having a personal history of certain blood disorders such as myelodyplastic syndrome (MDS), are also risk factors.
Bicalutamide was first reported in the literature in June 1987 by Furr et al.
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As the use of hormone therapy has expanded to other situations, questions about when to initiate therapy may also come up.
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Psa would go up and go down after treatment.
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Bicalutamide is a an anti androgen.
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Severe penile hematoma was also reported as an adverse reaction in 39 of 1044 (3.
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Androgens inhibit proliferation in a concentration-dependent manner to about 30% of the maximal cell count (Figure 2A).
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We believe that it is very important that W741C mutant AR, which showed aberrant response to bicalutamide, was not generated in the laboratory but in a patient treated with bicalutamide, the most widely used pure nonsteroidal antiandrogen.
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